H-TYR-GLY-GLY-PHE-MET-OH CAS 58569-55-4

TYR-D-ALA-GLY-PHE-LEU CAS 64963-01-5 uses and synthesis methods

• Biological activity

Tyr-Gly-Gly-Phe-Met-OH can regulate human immune function and inhibit tumor growth by binding to opioid receptors.

• Target  

Opioid Receptor.

• In vitro studies

Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems.MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems.

• Chemical properties 

White or off-white powder, composed of 5 amino acids, in order: L-tyrosine, glycine, L-phenylalanine, and L-methionine.

• Use 

For biochemical research, neurobiological research.

• Production method

Using L-tyrosine, glycine, L-phenylalanine, and L-methionine as raw materials, the side chains of the amino acids with side chains in the amino acids are first protected with protective agents according to their characteristics, and then the polypeptide is condensed. The condensation reaction is carried out in the presence of the mixture, and then the protective agent is removed and purified.