Cell Adhesive Peptide CAS 109292-46-8

Cell Adhesive Peptide CAS 109292-46-8 properties, Uses and Production Process

• Biological activity

Arg-Gly-Asp-Cys is the binding motif between fibronectin and cell adhesion molecules and can inhibit platelet aggregation and fibrinogen binding.

• Discovery

Synthetic cell adhesion peptides were first derived from laminin. The peptide PA22-2 (CSRARKQAASIKVAVSADR-NH2) derived from laminin was found to function as a cell adhesion molecule which was tested with mouse mast cells1.

• Classification

Cell adhesion peptides for the most part are extracellular matrix proteins1.

• Structural Characteristics

Numerous cell adhesion peptides have been synthesized to date.  Some examples include: RU-1 (LNIVSVNGRHX), RX-1 (DNRIRLQAKXX), GD-1 (KATPMLKMRTSFHGCIK), GD-2 (KEGYKVRLDLNITLEFRTTSK), GD-3 (KNLEISRSTFDLLRNSYGVRK), GD-6 (KQNCLSSRASFRGCVRNLRLSR), HGD-6 (KQKCLRSQTSFRGCLRKLALIK), SGD-6 (CRNRGRCNSSLFQVRSRKLLSA), HSGD-6 (KQCLKSQRSFTRGLCRLKAKIL), AG-1 (KLLISRARKQÁASIK), F17 (LERKYENDQKYLEDKA) and KRGD (VEKRGDREEA).  Peptides that are linear and cyclic in nature have been synthesized2.

• Mode of action

Cell adhesion peptides can bind to the cell membrane and trigger adhesion of cells3.

• Functions

Cell adhesion peptides have known to increase signaling via receptors3.  They have been shown to decrease tumor metastasis and growth in experimental animals3.  These peptides also induce Ca2+ signaling and modulate platelet activity3.