AC-SER-LEU-VAL-OH CAS 189109-90-8

• Overview

Fas C-terminal tripeptide, the chemical formula is C16H29N3O6, is a tripeptide with the sequence AC-SER-LEU-VAL-OH. This is the C-terminal tripeptide of Fas antigen with a molecular weight of 359.4. FAS (APO-1/CD95) is a cell membrane receptor that belongs to the tumor necrosis factor receptor (TNFR) superfamily. FAS receptor is a membrane receptor that mediates programmed cell death (apoptosis) and is one of the apoptosis pathways. The ligand binds to Fas to form the death- inducing signaling complex (DISC). Then the death domain (DD) polymerizes and transports the receptor complex into the cell through the lysosomal mechanism. The regulatory molecule FADD binds to the Fas death domain through its own death domain. There is also a death effector domain near the amino terminus of FADD. (DED), which facilitates the binding of FADD-like interleukin-1β converting enzyme (FLICE) to DED, commonly known as caspase-8. FLICE completes its self-activation through proteolysis into P10 and P18 subunits. Two of each subunit of P10 and P18 form an active heterotetramerase. Subsequently, caspase-8 is released from DISC into the cytosol and cleaves other effector caspases, ultimately leading to DNA degradation, membrane blebbing, and other apoptotic hallmarks of apoptosis.

The C-terminal tripeptide of Fas (AC-SER-LEU-VAL-OH) can bind to the third PDZ structure of FAP-1 and inhibit the binding of Fas/FAP-1.