Ibudilast CAS 50847-11-5

Ibudilast CAS 50847-11-5 Chemical Properties,Uses,Production

• Biological activity

Ibudilast (KC-404, AV411, MN166) is a relatively non-selective phosphodiesterase inhibitor with anti-inflammatory and neuroprotective activities.

• Target

• Chemical properties

Colorless plate crystal or white crystalline powder, melting point 53.5-54℃ (hexane). Easily soluble in organic solvents, slightly soluble in water. Acute toxicity LD 50 male and female mice,male and female rats (mg/kg): 1880, 1860, 1340, 1390 oral; > 3000, 3100, 1450, 1300 subcutaneous injection; 460, 500, 550, 419 intraperitoneal injection ;160, 146, 43.2, 42.5 intravenous injection.

• Use

Used for bronchial asthma, it can improve the subjective symptoms of patients with sequelae of cerebral infarction, sequelae of cerebral hemorrhage and cerebral arteriosclerosis.

• Production method

1-Amino-2-methylpyridine anchor halide and isobutyric anhydride react in the presence of potassium carbonate and sodium acetate to obtain ibudilast.