4-Chlorobenzophenone CAS 134-85-0

4-Chlorobenzophenone CAS 134-85-0 Chemical Properties,Uses,Production

• Application

4-Chlorobenzophenone is an off-white or off-white to reddish-white crystal.It is a raw material for the synthesis of pharmaceutical and pesticide products such as the anti-hyperlipidemic drug fenofibrate and the preparation of heat-resistant polymers. It has a wide range of uses. In addition, 4-chlorobenzophenone, as an important chemical intermediate, is widely used in medicine, pesticides, dyes and other organic synthesis.

• Resolve Resolution

Combine 4-chlorobenzoyl chloride (1.5mmol), phenylboronic acid (1.25mmol), and sodium carbonate (133mg, 1.25mmol). Flush the tube with argon.Seal the tube with a rubber septum. Add toluene and water (3 each) to the test tube. mL). Transfer the reaction vessel to an oil bath maintained at 50 °C.Stir the mixture for 1 h. Transfer the reaction mixture to a separatory funnel. Dilute the mixture with diethyl ether (20 mL). Separate the aqueous phase. Separate the aqueous phase with 3 M HCl ( twice), 5% KOH (four times) and brine (twice).Dry the organic phase over anhydrous magnesium sulfate. Pre-adsorb the crude product by evaporating the organic phase under vacuum over chromatography grade silica gel.Use hexane-ethyl acetate The product was purified by column chromatography on silica gel (30:1, 10:1 or 5:1 v:v). The product was evaporated to give the title compound 4-chlorobenzophenone.

                                                    Figure 4-Synthetic route of chlorobenzophenone

• Chemical Properties 

 Off-white crystalline powder 

•  Use 

 UV curable coatings and inks

• Use 

Pharmaceutical intermediates

• Use 

Used as pharmaceutical and pesticide intermediates

• Production Method

Obtained from the condensation of benzoyl chloride and chlorobenzene: In a dry reaction pot, add chlorobenzene and anhydrous aluminum trichloride,stir and raise the temperature to 50°C, and add benzoyl chloride dropwise. After the addition, react at 100-110°C for 5.5 hours, slowly add slightly acidic ice water, stir well and let it stand, separate the supernatant, filter, wash until neutral, and spin dry to obtain 4-chlorobis benzophenone.