3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride CAS 762240-92-6

CAS 762240-92-6 Chemical Properties,Uses,Production

• Use

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride is mainly used as a pharmaceutical intermediate.

• Application

• Resolve Resolution

China Pharmaceutical University Han Xun et al. used ethyl trifluoroacetate as the raw material, reacted with hydrazine hydrate through hydrazinolysis to prepare compound 5, and used ethyl chloroacetate as the raw material, reacted with ethylenediamine through substitution and cyclization to prepare compound 2 , compound 2 and Boc acid anhydride undergo a substitution reaction to obtain compound 3, compound 3 and phosphorus pentasulfide undergo a sulfo reaction to obtain compound 4, compound 4 and compound 5 undergo a substitution, cyclization, and de-Boc reaction to form a salt to obtain the target compound 1, that is, (3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride), modified total The rate is 45.7%.