4-Chlorobenzhydrol CAS 119-56-2

4-Chlorobenzhydrol CAS 119-56-2 Chemical Properties,Uses,Production

• Purpose 1
  

Used in the manufacture of the anti-allergic drug cetirizine

• Method one

It is obtained by condensation and reduction of benzoyl chloride. 1. Condensate in a dry reaction pot, add chlorobenzene and anhydrous aluminum trichloride, stir and raise the temperature to 50°C, and add benzoyl chloride dropwise. After the addition is completed, react at 100-110°C for 5.5 hours. Slowly put it into slightly acidic ice water, stir well and let it stand. Remove the supernatant, precipitate and filter, wash with water until neutral, and spin dry. Obtain 4-chlorobenzophenone. The yield is 95%. 2. Reduction Add 4-chlorobenzophenone and liquid caustic soda to the reaction pot, stir and raise the temperature to 100°C, slowly add zinc powder, and control the temperature at 110-125°C. After adding, react for 8 hours. Let it stand, separate the oil layer, wash it with hot water and a small amount of hydrochloric acid, then wash it with hot water until the pH is 6.5, add benzene and stir to dissolve. Leave to stand, separate the benzene layer, steam the benzene, and the remaining liquid is the finished product.